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● Neurologie praktijk ●

Wetenschappelijk onderzoek

  • The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Cornelissen T, Haddad D, Wauters F, Van Humbeeck C, Mandemakers W, Koentjoro B, Sue C, Gevaert K, De Strooper B, Verstreken P, Vandenberghe W. Hum Mol Genet. 2014 Oct 1;23(19):5227-42. doi: 10.1093/hmg/ddu244. Epub 2014 May 22. http://www.ncbi.nlm.nih.gov/pubmed/24852371
  • Ambra1: a Parkin-binding protein involved in mitophagy. Van Humbeeck C, Cornelissen T, Vandenberghe W. Autophagy. 2011 Dec;7(12):1555-6.
    http://www.ncbi.nlm.nih.gov/pubmed/21921694
  • Parkin interacts with Ambra1 to induce mitophagy. Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, Vandenberghe W. J Neurosci. 2011 Jul 13;31(28):10249-61.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253705/
  • Parkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain. Van Humbeeck C, Waelkens E, Corti O, Brice A, Vandenberghe W.Eur J Neurosci. 2008 Jan;27(2):284-93.
    http://www.ncbi.nlm.nih.gov/pubmed/18190519